Upon confronting his best friend's past-self, Sasuke was amazed to learn how even back then how committed Naruto was to save Sasuke from his dark path. Sasuke decided to do what Itachi had instructed and dedicated his life to vengeance, having no other interest than bringing about Itachi's death. She transports them to one of Sasuke wanders the dunes, finding the spot where Naruto's chakra signature is strongest. Naruto and Sasuke assist with evacuating all the prisoners the Land of the Sky has taken. The artefact turned out to be a turtle belonging to the Ōtsutsuki name Realising Urashiki's plan was to acquire Kurama's chakra from Naruto as a child, Sasuke asked Karasuki about the enemy. Sasuke maintains contact with Sai when Konoha is attacked and discovers the origins of the Dark Thunder Group. Jigen later attacked Konohagakure and sent Naruto to an unknown dimension. He meets the Sound Four outside the village and they start guiding him to Orochimaru. Sasuke is unable to answer any of the questions, causing him to realise that the purpose of the first stage is to cheat without getting caught. Suspicious, Sasuke tells her to kill Karin to prove her loyalty but, as she nears Karin, Karin warns her that Sasuke is attacking her from behind. There, he also discovered another Ten-Tails imprisoned. When this doesn't work, Sakura confesses her love for him and asks to be allowed to accompany him at the very least. Sasuke and Naruto clash with Chidori and Rasengan respectively, but their mental states connect. Sakura dissuade him by telling him she still loves him and pleading for him to return home if he ever loved her. Although he fulfills Itachi's wish for him to protect Konoha, doing this from the shadows and investigating the mysteries of Kaguya leave him unable to spend time with his family, to the point of even failing to recognise his daughter, Sarada. At the same time, he is willing to acknowledging significant events as he sent a note congratulating Naruto for his wedding. There he learned from Boruto of the new village holiday, Parent and Child Day. Along the way, having realised that the Eight Trigrams Sealing Style was stopping Urashiki from stealing the Nine-Tail's chakra, Jiraiya placed powerful seals on Boruto and Sasuke to protect them as well. While Sarada was overjoyed at the idea, the normally poised man struggled to connect with his daughter, simply trying to get inspiration wherever he could, instead simply embarrassing Sarada. Seeing her with the Sharingan and having the Uchiha crest on her back, Sasuke suspects she is connected to the boy and almost attacks her until she calls out to him as dad, and he realises she is his own daughter. After Amado was officially made a citizen of Konohagakure, he explained that Isshiki's resurrection was unstable and would seek out Kawaki again to rebrand him. Sakura asks what is happening but Sasuke tells her and then Kakashi they don't need to know because there is nothing they can do and assumes leadership of Team 7 because he believes only he can stop the Infinite Tsukuyomi with his Rinnegan. Sasuke becomes angry and asks Naruto why he would go so far for him, to which Naruto responds that Sasuke is like a brother to him and that he simply can't let him go. He concludes that this is the key to Danzō's survival and that, when all eyes close, he won't be able to avoid injury anymore; Danzō confirms this as Satisfied with his revenge on Danzō, Sasuke states his intentions to continue on to Konoha.

Sasuke then explained all he knew about the alien's abilities. It isn't until Naruto brings Kakashi tracks Sasuke down afterwards and lectures him; the Chidori is supposed to be used to protect friends, not attack them. Finally having enough, Sarada stormed off. Before they could formulate a proper plan, Sasuke detected Urashiki's return, speeding off with Jiraiya to help Boruto and Naruto. Guilt-ridden for the pain he put Sakura through, Sasuke tries to speak to her but she tells him not to because she needs to concentrate on healing them. The following day, after Sasuke used his Sharingan to Afterwards, with the growing threat of Kara, Sasuke feared for his disciple's safety and instructed him to keep his Kāma hidden from all at all cost, so as to not draw attention to himself. The impact of their attacks sends them flying and Sasuke is saved by Tobi. He discovered an Ōtsutsuki related site, which contained records on some of their members, specifically those who had been to their world, which also led him to believe Kaguya came to this world with a partner. Because his current host body is in the process of rejecting him anyway, Orochimaru vacates it and attempts to take Sasuke's. Sasuke attacks and defeats Itachi with his Sasuke and Itachi abandon genjutsu and switch to ninjutsu.